Studies in detoxication. 49. The metabolism of benzene containing [14C1]benzene

Studies in detoxication. 30. The metabolism of benzene. (a) The determination of benzene. (b) The elimination of unchanged benzene by rabbits.

53 Studies in Detoxication

The octyl alcohol, DL-2-ethyl-fl-hexanol, is used industrially as a solvent and, in the form of the ester, di-2-ethylhexyl phthalate, as a plasticizer. According to Shaffer, Carpenter & Smyth (1945) this ester is saponified in rats and rabbits, phthalic acid being excreted and there being also an increase in the short-chain fatty acids in the urine. After feeding the DL-alcohol to rabbits, Akiy...

Studies in detoxication: 14. The metabolism of veratraldehyde and veratric acid in the rabbit.

The work described in this paper had two objectives. First, it was hoped that a more stable aroylglucuronide (veratroylglucuronide and anisoylglucuronide) than benzoylglucuronide (Quick, 1926; Pryde & Williams, 1933; Goebel, 1938) could be prepared for constitutional studies. In the second place, it was considered possible' that a comparative study of the metabolism of veratric acid (3:4-dimeth...

Studies in detoxication. 60. The metabolism of alkylbenzenes: isopropylbenzene (cumene) and derivatives of hydratropic acid.

isoPropylbenzene (cumene) is used as a solvent for cellulose lacquer, although not extensively. It has narcotic properties but no toxic effects in man have been reported (see Browning, 1953). When fed to rabbits it causes the excretion of considerable amounts of conjugated glucuronic acid and the urine reduces Benedict's reagent (Smith, Smithies & Williams, 1954a), but nothing definite is known...

Studies in detoxication. 63. The metabolism of halogenobenzenes; (a) meta-dichlorobenzene (b) further observations on the metabolism of chlorobenzene.

2. o-Dichlorobenzene also gives rise to 3:4dichlorophenylmercapturic acid as a minor metabolite (5% of the dose). 3. p-Dichlorobenzene (0.5 g./kg.) is mainly oxidized to 2:5-dichlorophenol which is excreted conjugated. 2:5-Dichloroquinol is also formed (about 6% of the dose) but in contrast with o-dichlorobenzene no mercapturic acid or dichlorocatechol is formed. 4. The excretion ofthe metaboli...